Persistent Host Markers in Pandemic and H5N1 Influenza Viruses▿
Identifieur interne : 000111 ( 1957/Analysis ); précédent : 000110; suivant : 000112Persistent Host Markers in Pandemic and H5N1 Influenza Viruses▿
Auteurs : David B. Finkelstein ; Suraj Mukatira ; Perdeep K. Mehta ; John C. Obenauer ; Xiaoping Su ; Robert G. Webster ; Clayton W. NaeveSource :
- Journal of Virology [ 0022-538X ] ; 2007.
Abstract
Avian influenza viruses have adapted to human hosts, causing pandemics in humans. The key host-specific amino acid mutations required for an avian influenza virus to function in humans are unknown. Through multiple-sequence alignment and statistical testing of each aligned amino acid, we identified markers that discriminate human influenza viruses from avian influenza viruses. We applied strict thresholds to select only markers which are highly preserved in human influenza virus isolates over time. We found that a subset of these persistent host markers exist in all human pandemic influenza virus sequences from 1918, 1957, and 1968, while others are acquired as the virus becomes a seasonal influenza virus. We also show that human H5N1 influenza viruses are significantly more likely to contain the amino acid predominant in human strains for a few persistent host markers than avian H5N1 influenza viruses. This sporadic enrichment of amino acids present in human-hosted viruses may indicate that some H5N1 viruses have made modest adaptations to their new hosts in the recent past. The markers reported here should be useful in monitoring potential pandemic influenza viruses.
Url:
DOI: 10.1128/JVI.00921-07
PubMed: 17652405
PubMed Central: 2045501
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000388
- to stream Pmc, to step Curation: 000388
- to stream Pmc, to step Checkpoint: 000B49
- to stream Ncbi, to step Merge: 000234
- to stream Ncbi, to step Curation: 000234
- to stream Ncbi, to step Checkpoint: 000234
- to stream Main, to step Merge: 001378
- to stream Main, to step Curation: 001365
- to stream Main, to step Exploration: 001365
- to stream 1957, to step Extraction: 000111
Links to Exploration step
PMC:2045501Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent Host Markers in Pandemic and H5N1 Influenza Viruses<xref ref-type="fn" rid="fn1">▿</xref>
</title>
<author><name sortKey="Finkelstein, David B" sort="Finkelstein, David B" uniqKey="Finkelstein D" first="David B." last="Finkelstein">David B. Finkelstein</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mukatira, Suraj" sort="Mukatira, Suraj" uniqKey="Mukatira S" first="Suraj" last="Mukatira">Suraj Mukatira</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehta, Perdeep K" sort="Mehta, Perdeep K" uniqKey="Mehta P" first="Perdeep K." last="Mehta">Perdeep K. Mehta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Obenauer, John C" sort="Obenauer, John C" uniqKey="Obenauer J" first="John C." last="Obenauer">John C. Obenauer</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Su, Xiaoping" sort="Su, Xiaoping" uniqKey="Su X" first="Xiaoping" last="Su">Xiaoping Su</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Naeve, Clayton W" sort="Naeve, Clayton W" uniqKey="Naeve C" first="Clayton W." last="Naeve">Clayton W. Naeve</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17652405</idno>
<idno type="pmc">2045501</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045501</idno>
<idno type="RBID">PMC:2045501</idno>
<idno type="doi">10.1128/JVI.00921-07</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000388</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000388</idno>
<idno type="wicri:Area/Pmc/Curation">000388</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000388</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B49</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B49</idno>
<idno type="wicri:Area/Ncbi/Merge">000234</idno>
<idno type="wicri:Area/Ncbi/Curation">000234</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000234</idno>
<idno type="wicri:doubleKey">0022-538X:2007:Finkelstein D:persistent:host:markers</idno>
<idno type="wicri:Area/Main/Merge">001378</idno>
<idno type="wicri:Area/Main/Curation">001365</idno>
<idno type="wicri:Area/Main/Exploration">001365</idno>
<idno type="wicri:Area/1957/Extraction">000111</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Persistent Host Markers in Pandemic and H5N1 Influenza Viruses<xref ref-type="fn" rid="fn1">▿</xref>
</title>
<author><name sortKey="Finkelstein, David B" sort="Finkelstein, David B" uniqKey="Finkelstein D" first="David B." last="Finkelstein">David B. Finkelstein</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mukatira, Suraj" sort="Mukatira, Suraj" uniqKey="Mukatira S" first="Suraj" last="Mukatira">Suraj Mukatira</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehta, Perdeep K" sort="Mehta, Perdeep K" uniqKey="Mehta P" first="Perdeep K." last="Mehta">Perdeep K. Mehta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Obenauer, John C" sort="Obenauer, John C" uniqKey="Obenauer J" first="John C." last="Obenauer">John C. Obenauer</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Su, Xiaoping" sort="Su, Xiaoping" uniqKey="Su X" first="Xiaoping" last="Su">Xiaoping Su</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Naeve, Clayton W" sort="Naeve, Clayton W" uniqKey="Naeve C" first="Clayton W." last="Naeve">Clayton W. Naeve</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Avian influenza viruses have adapted to human hosts, causing pandemics in humans. The key host-specific amino acid mutations required for an avian influenza virus to function in humans are unknown. Through multiple-sequence alignment and statistical testing of each aligned amino acid, we identified markers that discriminate human influenza viruses from avian influenza viruses. We applied strict thresholds to select only markers which are highly preserved in human influenza virus isolates over time. We found that a subset of these persistent host markers exist in all human pandemic influenza virus sequences from 1918, 1957, and 1968, while others are acquired as the virus becomes a seasonal influenza virus. We also show that human H5N1 influenza viruses are significantly more likely to contain the amino acid predominant in human strains for a few persistent host markers than avian H5N1 influenza viruses. This sporadic enrichment of amino acids present in human-hosted viruses may indicate that some H5N1 viruses have made modest adaptations to their new hosts in the recent past. The markers reported here should be useful in monitoring potential pandemic influenza viruses.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Finkelstein, David B" sort="Finkelstein, David B" uniqKey="Finkelstein D" first="David B." last="Finkelstein">David B. Finkelstein</name>
<name sortKey="Mehta, Perdeep K" sort="Mehta, Perdeep K" uniqKey="Mehta P" first="Perdeep K." last="Mehta">Perdeep K. Mehta</name>
<name sortKey="Mukatira, Suraj" sort="Mukatira, Suraj" uniqKey="Mukatira S" first="Suraj" last="Mukatira">Suraj Mukatira</name>
<name sortKey="Naeve, Clayton W" sort="Naeve, Clayton W" uniqKey="Naeve C" first="Clayton W." last="Naeve">Clayton W. Naeve</name>
<name sortKey="Obenauer, John C" sort="Obenauer, John C" uniqKey="Obenauer J" first="John C." last="Obenauer">John C. Obenauer</name>
<name sortKey="Su, Xiaoping" sort="Su, Xiaoping" uniqKey="Su X" first="Xiaoping" last="Su">Xiaoping Su</name>
<name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000111 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000111 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= 1957 |étape= Analysis |type= RBID |clé= PMC:2045501 |texte= Persistent Host Markers in Pandemic and H5N1 Influenza Viruses▿ }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i -Sk "pubmed:17652405" \ | HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |